Born in Baltimore and raised in small town Pennsylvania, Speace initially had her sights set on a career as a playwright/actor, graduating from Amherst College and toured with the prestigious National Shakespeare Company. After moving to New York, she had roles in various off Broadway productions and independent films, ran her own theater company, and taught Shakespeare in the New York City school system. After teaching herself to play guitar, she began setting her poetry to music, and quickly found songwriting to be the most creatively fulfilling thing she'd ever done. She soon began performing as half of the female duo Edith O. Speace made her solo debut with the 2002 release Fable, recorded with $5000 donated by fans and released on her own Twangirl label. Giving up her hard-won acting career to become a full time musician, she hopped into her car and hit the road, booking herself into every club, café and college that would have her. After catching a performance at the SXSW music industry festival, Judy Collins' manager brought Speace to the attention of Collins, who signed her to her Wildflower label. Her debut for the label, Songs For Bright Street, received warm praise from critics, including those in Europe, which has enabled her to build a strong touring base there.